Compare carboplatin vs cytoxan comprehensive analysis by. It is also used with doxorubicin hydrochloride and cyclophosphamide to treat breast cancer that is node. Litigation over the cancer drug taxotere is popping up all over the country. She experienced severe body pain but painkillers were able to fix that. A dose of 100 mgm 2 in patients previously treated with chemotherapy was associated with increased hematologic toxicity, infection, and. Taxotere is a newer chemotherapy agent that kills cancer cells in a similar manner. Instead of a large dose of taxotere along with a side of carboplatin every three weeks, i am now getting a smaller dose of taxol weekly. Prescribed for breast cancer adjuvant, breast cancer metastatic, breast cancer, kaposis sarcoma, nonsmall cell lung cancer, ovarian cancer, wilms tumor. No i never had pain or nausea with either ac or taxol could not sleep without pills, lived on the couch or bed for all 12 of them. Pazdur r1, kudelka ap, kavanagh jj, cohen pr, raber.
Sanofi brought taxotere to the fda in 1994, two years before taxol was approved. Both are used in treatment of many cancers breast, lung, ovary, headneck, stomach, esophageal, prostate, etc. Taxol paclitaxel dosing, indications, interactions. From what i understand taxotere is very similarto taxol except it was developed because many people experienced neuropathy from the taxol.
Taxotere is a chemotherapy drug used for the treatment of breast cancer. Taxol paclitaxel remove taxol from your drug comparison. Taxol asked by banditwalker on saturday, november 23, 20 ac vs. So far, ill still keep my every three weeks carbo schedule. Rabertt department of gastrointestinal oncology and digestive diseases, tdepartment of breast and gynecologic medical oncology, epartment of medical specialities, ttdepartment of clinical. Multiple longterm studies have proven that there is no statistical difference in survival rates between taxol and taxotere for the treatment of breast cancer that has spread to the lymph nodes or presents the risk of spreading. Docetaxel is a member of a family of drugs called taxanes. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. While taxol is supposed to be gentler on the heart, it can cause severe allergic reactions. This emedtv article briefly discusses the potential benefits of taxotere and provides a link to more information on this type of chemotherapy. I had a reaction to taxol and they changed me to taxotere. Docetaxel and paclitaxel comparing the two taxanes. Taxol is an anticancer antineoplastic or cytotoxic chemotherapy drug. Selected from data included with permission and ed by first databank, inc.
Taxanes interfere with the ability of cancer cells to divide. Noting how little information was available on docetaxel side effects, the fdas oncologic drugs advisory committee unanimously recommended denying sanofis approval application. But due to loss of appetite and not drinking enough fluids, she had low bp due to which they ended up giving her fluid ivy twice. Obviously both have side effects, but the 18 week course of taxotere and carboplatin is what i had with. Taxol weekly better than every three weeks for breast cancer. Taxol is a type of chemotherapy extracted originally from the pacific yew tree taxotere is a synthetic drug that works similarly. Taxotere usually is given in combination with other chemotherapy medicines and is used after surgery to treat. This study found that women diagnosed with hormonereceptorpositive. I chose to do the 12 weekly taxol as dr said it was the most aggressive plan and i was going to do everything that was possible to do. Taxotere i had taxol two years ago and yes i lost my eyelashes and eyebrows and suffered terrible bone pain for about 2 days after each treatment and i developed mouth sores which made eating certain foods difficult.
Docetaxel is approved to be used alone or with other drugs to treat breast cancer that is locally advanced or has metastasized spread to other parts of the body and has not gotten better with other chemotherapy. Taxol for the treatment of nonsmall cell lung cancer. Taxol has been used extensively in the treatment of breast cancer. The drug was subsequently approved in the united states, with the standard of care being four doses once every three weeks. Researchers from canada conducted a clinical trial to compare taxotere to taxol in the treatment of patients with metastatic breast cancer. The good news is that the administration time is 1 hour as compared to the 3. Chicago breast cancer patients obtained the same disease control with less toxicity when they received weekly lowdose chemotherapy instead of a.
Paclitaxel taxol and docetaxel taxotere are among the most unique, and successful, chemotherapeutic agents used for the treatment of breast and ovarian. Taxal is paclitaxel, toxotere is docetaxel classified as plant alkaloids, have similar properties, commonly used in breast cancer, small cell lung cancer, met prostate cancer ge junction gastric cancers. Taxol paclitaxel is a drug used in the treatment of nonsmall cell lung cancer. Approximately onehalf of patients had received prior chemotherapy for metastatic disease, and onehalf entered the study following relapse after adjuvant therapy. The taxotere is often given if you have an allergic reaction to taxol. Nab paclitaxel nanoparticule albuminbound paclitaxel nab paclitaxel. About a decade ago, a study showed that adding taxol to standard chemo reduced the risk of breast cancer recurrence. Taxotere is used to treat breast cancer, nonsmall cell lung cancer, advanced stomach cancer, head and neck cancer as well as metastatic prostate cancer. I did round one six scheduled cycles of taxol and carboplatin with no incident. Taxotere and taxol are two taxanes, a group of chemotherapy agents used to treat advanced or metastatic breast cancer in patients that did not respond to prior therapies. Listing a study does not mean it has been evaluated by the u.
I went for round two today and after 1 hour of premeds 10 minutes into the taxol i pitched forward, got very hot all over, had diffuculty breathing, got an extremely bad metal taste in my mouth much worse than the one from. One of the big differences in the taxol and taxotere is the solution the drug is prepared in. Paclitaxel is used to treat various types of cancer. Taxotere docetaxel remove taxotere from your drug comparison. Abraxane is a novel paclitaxel formulation, which does not containcremophorel16,17. The other taxane, taxotere docetaxel is more potent than taxol. It is given via intravenous infusion, sometimes in combination with other chemo drugs. For me taxol caused me to have neuropathy, and altered my tastebuds. Paclitaxel and docetaxel are the two presently clinically available representatives of. Docetaxel is usually administered as a 1h infusion every 3weeks15. These results suggest a more favorable benefittorisk ratio for docetaxel compared to paclitaxel when these drugs are used as single agents or in combination.
Taxotere is an intravenous injection manufactured by sanofiaventis. The drug is manufactured by sanofi, a french multinational pharmaceutical corporation. Docetaxel is an antineoplastic chemotherapy drug, used to inhibit or stop the development of cancerous tumors. Both are given every 34 weeks but taxol is given every week fashion too.
According to studies, taxotere showed more benefits to survival than taxol paclitaxel, another chemotherapy drug in the same class. The taxol would be taken weekly for 12 weeks as opposed to the ac which would be 1 time every three weeks for 12 weeks. A generic version of docetaxel, manufactured by hospira, was approved in 2011. Weekly doses of taxol prolonged lives of breast cancer. Although hair loss is very common with many chemotherapy agents used to treat breast cancer, permanent hair loss should not occur. The taxoids, paclitaxel taxol and docetaxel taxotere, represent a novel class of antineoplastic drugs. The immunopharmacology of paclitaxel taxol, docetaxel taxotere. Sometimes it is not safe to use certain medications at the same time. Reversible marrow suppression was the major doselimiting toxicity of taxotere see warnings and precautions. Onc has given us three options to chose from for the next round 1continue with lower dosage of taxotere every. Paclitaxel and docetaxel share a similar mechanism of action.
These drugs are administered via an infusion drip into a vein through a small and very thin plastic tube called a cannula. The effects of taxoids taxol and taxotere were followed on two human cancerous cell lines bladder carcinoma j82 cells and epidermoid carcinoma kb 31 cells. But the federal agency was worried about taxoteres incredibly high toxicity. A cycle of treatment comprises of an hour premedication, and a 1hour infusion of taxotere followed by a 30minute infusion of carboplatin. Cisplatin vs paclitaxel for triple neg full text view. What other drugs will affect paclitaxel onxol, taxol. During the debate over taxotere vs taxol, oncologists may.
Fda label information for this drug is available at dailymed. One study that analyzed the effects of taxotere found that up to 9. Cisplatin vs paclitaxel for triple neg the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Of course, many cancer patients seek treatment options that promise the best longterm, diseasefree survival rates. Taxotere is classified as a cytotoxic drug, which is a drug that stops rapidly dividing cells. Ituseshumanserumalbumin to encapsulate hydrophobic paclitaxel molecules in particles of around nm 18. If you have breast cancer or nonsmall cell lung cancer, your healthcare provider may recommend taxotere. For treatment after failure of prior platinumbased chemotherapy, taxotere was evaluated as monotherapy, and the recommended dose is 75 mgm 2 administered intravenously over 1 hour every 3 weeks. Difference between taxol and taxotere doctor answers.
The amount of taxol and the schedule that it is given will receive depend on many factors, including your height and weight, your. The older chemotherapy agent produced by bristolmyers squibb has been one of the most widely used drugs in the adjuvant treatment of breast cancer since. Taxol was bad i was completelyutterly exhausted the entire time. Compare abraxane vs taxol headtohead with other drugs for uses, ratings, cost, side effects, interactions and more. Taxotere understanding the chemotherapy drug docetaxel. The clinical development of paclitaxel was initially hampered by hypersensitivity reactions hsrs. Nabrinsky on difference between taxol and taxotere. Taxotere is a much more potent drug than taxol, meaning that the same effect can be achieved with lower a dose. It is a cancer chemotherapy drug that works by slowing or stopping cancer cell growth. How taxol chemotherapy is given and possible side effects. Taxotere is taxol suspended in a solution that minimizes those side effects. Even if this may seem like a positive aspect of the newer agent, docetaxel is still associated with significant toxicity and a higher risk of developing drug resistance, which forces doctors to increase the dosage progressively. If you have any questions, consult your doctor or pharmacist. Because i was getting painful neuropathy in my hands and feet, my doctor decided to switch my chemo regimen half way through.
Information regarding the differences between the chemotherapy drugs docetaxel taxotere and paclitaxel taxol used in the treatment of breast cancer. In addition, some advanced pancreatic cancer patients may be treated with taxol infusions. The median time to nadir was 7 days, while the median duration of severe neutropenia taxotere. Adriamycin is hard on the heart and supposedly has more side effects. This medication is used to treat cancer such as breast, lung, prostate, stomach, and headneck cancer. Chemoqueen i found the website but no reference to your trial. Primarily prescribed to treat breast, lung as well as ovarian cancers, taxol belongs to the taxane drug class along with taxotere. Both paclitaxel taxol and docetaxel taxotere are highly effective at treating breast cancer, and both work by attacking the skeletons of cells, preventing them from dividing. Lowdose weekly administration of this chemotherapy is less toxic but as effective as the dosedense option for women with highrisk breast cancer. Hang in there you will soon be done and on your way to. Doctors give trusted answers on uses, effects, sideeffects, and cautions. Read the patient information leaflet available from your pharmacist before you start using paclitaxel. Taxol paclitaxel taxotere docetaxel has been vastly advertised by its manufacturer sanofiaventis, as a newer, more effective alternative to taxol paclitaxel. It is usually given over 2 hours every 3 weeks, as an outpatient.